Vaping CBD Causes More Severe Lung Damage Than Vaping Nicotine, Roswell Park Study Shows

New study in Thorax is first to document comparative health effects of vaping cannabidiol

  • Vaping CBD linked to increased inflammation & oxidative stress vs. nicotine
  • Health effects evident after short-term exposure
  • Findings underscore importance of asking patients about all forms of smoking

BUFFALO, N.Y. — Vaping cannabidiol (CBD), a compound found in marijuana, leads to more severe lung damage than vaping nicotine, according to a study out of Roswell Park Comprehensive Cancer Center. Until now, research on the health effects of vaping, or using e-cigarettes, has focused almost exclusively on vaping nicotine as opposed to CBD. Previous research has documented the effects of smoking cannabis, but the effects of vaping cannabinoids such as CBD were not previously known.

Led by Yasmin Thanavala, PhD, of the Department of Immunology, the Roswell Park team has conducted the first study comparing the pulmonary effects of acute inhalation of vaporized CBD and nicotine. The results are shared in a new research paper, “Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine,” published in the journal Thorax.
Vaping involves using a device that heats a liquid containing nicotine or other substances, such as CBD, to create an aerosol that can be inhaled. For this study, the team compared two commercial vaping products: a CBD product containing 50 mg/mL of CBD (natural flavoring), dissolved in a solution of medium chain triglycerides — fats derived from coconut or palm oils; and a nicotine product containing 5.0% nicotine (Virginia Tobacco flavor) dissolved in a solution of propylene glycol, a synthetic food additive, and vegetable glycerin, made from plant-based oils.

The preclinical study involved both in vivo models and in vitro cultures of human cells, which were exposed to filtered air, nicotine aerosols or CBD aerosols for two weeks. “We believe this is the first-ever report on what happens to various immune cell types and markers of damage and inflammation measured in the lung following in vivo inhalation exposure,” says Dr. Thanavala.

Among other results, the researchers found:

  • The number and severity of focal lesions — areas of tissue damage — in the lung were greater after inhalation of CBD aerosols than nicotine aerosols.
  • Myeloperoxidase (MPO) activity was significantly greater following exposure to CBD aerosol vs. nicotine aerosol. MPO, an enzyme, promotes inflammation and damage to lung cells.
  • Inhalation of CBD aerosols resulted in greater inflammatory changes and higher oxidative stress in the lung.
  • Exposure to CBD aerosols killed purified human neutrophils at a higher rate than nicotine aerosols (44.5% vs. 21%). Neutrophils in the lungs protect against bacteria, viruses and fungi.
  • CBD aerosols were more toxic to cultures of human small airway epithelial cells and disrupted the integrity of the lung epithelial barrier.
  • Inhalation of CBD aerosols resulted in significantly lower numbers of pulmonary interstitial macrophages compared with inhalation of nicotine aerosols (11,460 cells in CBD-vape vs. 27,727 cells in Nic-Vape). Among other roles, pulmonary interstitial macrophages are responsible for reducing inflammation and protecting against infection.

This work underscores how important it is for healthcare providers to zero in on the specifics of a patient’s smoking history, Dr. Thanavala notes, keeping in mind that for many people, the word “smoking” applies exclusively to smoking combustible cigarettes.

“Our findings suggest that vaping cannabis may not only cause significant lung injury, but can also increase susceptibility to respiratory infections, lead to poor responses to prophylactic vaccinations or cause worsening of symptoms in patients with underlying pulmonary inflammatory disease. So it’s not enough for care providers to ask people, ‘Do you smoke?’ The next step is, ‘Do you vape?’ If the answer is yes, you need to ask, ‘Do you vape nicotine or do you vape cannabis?’”

Dr. Thanavala and colleagues note: “While cannabis has proven health benefits in pain management, sleep, relieving the symptoms of chemotherapy-induced nausea/vomiting in cancer patients, and in patients experiencing seizures, there is simply a lack of robust evidence about cannabis safety when delivered from vaping products.”

They add that further research is needed — first, to investigate the long-term effects in people who regularly vape CBD and nicotine, and second, to evaluate the effects of vaping products that contain other types of cannabinoids, including tetrahydrocannabinol (THC), the psychoactive component of cannabis.

Tariq Bhat, PhD, Department of Immunology, served as first author of the paper. Other contributors include Suresh Kalathil, PhD, Department of Immunology; Maciej Goniewicz, PhD, Department of Health Behavior; and Alan Hutson, PhD, Department of Biostatistics.

Dr. Thanavala has been at the forefront of research on the health effects of vaping cannabinoids. In 2020 she led a team of researchers from Roswell Park and the National Center for Environmental Health at the Centers for Disease Control, who were first to report (in The New England Journal of Medicine) that a potentially fatal condition called EVALI — E-cigarette or Vaping use-Associated Lung Injury — was associated with vitamin E acetate, frequently used as a cutting agent in e-cigarette liquids containing THC, the psychoactive agent in cannabis.

The post Vaping CBD Causes More Severe Lung Damage Than Vaping Nicotine, Roswell Park Study Shows appeared first on Buffalo Healthy Living Magazine.

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Parker accused of shoving advocate at Capitol

With help from Shawn Ness

New from New York

Happening now:

  • Michael Carey, an advocate for disabled patients and a regular presence at the state Capitol, said he was pushed by state Sen. Kevin Parker.
  • Labor chairs of the state Legislature want to do more to protect retail workers.
  • Efforts to move migrants upstate to five counties has been slow going.
  • There was a new graduating class of the State Police today.
Michael Carey, a disability advocate who is fighting for legislation on behalf of his late son, said he was shoved twice by Brooklyn state Sen. Kevin Parker at an energy committee meeting in the Capitol.

CAPITOL FIGHT: State Sen. Kevin Parker allegedly shoved disability rights advocate Michael Carey before the start of the Senate Energy Committee meeting today, according to Carey and two other individuals who witnessed the altercation.

Carey, who is known to be vocal with lawmakers, shared with POLITICO a copy of a police report he filed, which can be read here.

In it, Carey alleges the lawmaker got in his face and screamed “I don’t care,” before putting his hands on him twice and shoving him in front of a room full of people, according to the report and a subsequent interview.

At the same time the incident was unfolding, shouting can be heard on the recording of the elections committee happening next door on the Capitol’s first floor.

Parker did not respond to multiple requests for comment from Playbook.

He is known for his explosive outbursts and physical altercations, which include allegedly shoving a legislative staffer, breaking a New York Post photographer’s camera and cursing out other lawmakers. Carey said he had been completely unaware of that history, which includes being convicted of a misdemeanor for the altercation with the Post photographer.

“This is multiple situations,” Carey said. “He's a danger to other people. He was a danger to me.”

The disability advocate said the incident started minutes before the committee meeting, when he asked Parker to cosponsor a 911 civil rights bill, which he is trying to make law in memory of his son who died in 2007 at a group home.

When Parker, chair of the energy committee, said he was looking into the matter, Carey said he told Parker the issue was analogous to Martin Luther King Jr.’s fight against discrimination and reminded Parker of his son's death. Parker then yelled “I don’t care” when Carey brought up his dead son and got inches away from Carey’s face before shoving him, according to Carey.

Witnesses, who were granted anonymity to discuss a sensitive matter, said Carey was also shouting at Parker during the incident.

Carey then said he left the meeting and requested a State Police officer come to the scene. He asked the officer to inform Parker that if he apologized to Carey he would not press charges. Parker did not apologize and instead invoked his right to counsel, Carey said.

“I was kind of shocked, he didn’t apologize,” he said.

State Sen. Mario R. Mattera, a Long Island Republican who serves as the ranking member on the Energy Committee, also said he witnessed the altercation but declined to go into detail.

“There was tensions, yes, there was tensions, and it was unfortunate in a lot of ways, but that's something that Senator Parker and that gentleman need to get through, and hopefully they can,” Mattera said.

He also said it was inappropriate for Carey to take up the issue of the bill at the committee meeting instead of trying to speak with Parker in his office.

Carey said he wants a restraining order against the senator.

“I understand when people don’t deal with anger issues, they’ll go on to hurt other people,” Carey said. — Jason Beeferman

The state Legislature's labor chairs said that Gov. Kathy Hochul needs to do more to crack down on retail theft.

RETAIL CRIME IS NOT OVER: Gov. Kathy Hochul pushed hard to get a budget deal that included cracking down on retail theft, but the Legislature’s labor chairs said that state government needs to go further to protect workers.

“There were some things done in the budget regarding retail workers that were punitive and all about law enforcement,” Assemblymember Harry Bronson, a Rochester Democrat, said. “We need more than that.”

The budget upgraded assaults on retail workers from a misdemeanor to a felony. It also created dedicated retail theft teams for state and local law enforcement and added $5 million in tax breaks for store security cameras and other anti-theft expenses.

But labor advocates say they need more proactive, instead of “punitive,” measures to protect retail workers.

They’re pushing for the Retail Worker Safety Act, sponsored by Bronson and state Sen. Jessica Ramos, that would require retailers in the state to train employees on de-escalation and violence prevention tactics.

The two lawmakers also rallied for three other labor bills this week: to reduce warehouse worker injuries; to set standards for extreme temperatures while working in agriculture, construction and other industries and a third to oversee nail salon workers’ rights.

“We have a very important decision to make on whether we're going to tilt the scales towards the workers or we're going to continue to allow for the scale to be tilted towards the bosses,” Ramos said Tuesday at a rally at the Capitol. “And I say no to that. I say, ‘Yes’ to protections for the workers.”

The Retail Council of New York State is working to counter Ramos and Bronson’s Retail Worker Safety Act.

“The costly mandates proposed in the bill — including onerous recordkeeping requirements, panic buttons and additional security guards — will do little, if anything, to address recidivists entering stores with the intent to engage in illegal activity such as shoplifting and assault,” Melissa O’Connor, the group’s president, wrote in a memorandum of opposition.

Justin Henry, a spokesperson for Hochul, did not comment on the labor chairs’ bills, but instead pointed to Hochul’s comments on the retail theft earlier this month:

“No one wants to see the shops in their neighborhood boarded up because business owners simply say, ‘I can't do this anymore. It's just not working. It's not worth it,’” Hochul said at a post-budget retail theft press conference. “That threatens the very vitality of these communities, which I will stop at nothing to protect.” — Jason Beeferman

The program designed to relocate migrant families outside New York City has only relocated 283 families to five counties across the state.

MIGRANT RELOCATION: After the state launched a program to relocate migrant families moving to New York City to upstate regions last August, it has only relocated 283 families, according to the Office of Temporary and Disability Assistance, which administers the program. Read the full story here.

Only five counties have received families: Albany, Erie, Monroe, Westchester and Suffolk; all of which have below-average housing vacancy rates. Nearly 1,000 families have been put on a waiting list or were deemed ineligible after being referred to the program.

“We're pretty much maxed out. We've been maxed out. I only have 320,000 residents in this county, and we already have a housing crisis,” said Albany County Executive Dan McCoy. “We're having issues putting people in housing.”

And plans to offer bonuses and incentives to landlords to join in on the program have not been very successful. Despite those woes, the state is still committed to relocating families.

“OTDA is committed to assisting migrant families that choose to relocate through the Migrant Relocation Assistance Program,” the agency said in a statement. — Shawn Ness

The new class of 228 state troopers have graduated from the police academy.

GRAD SZN: The State Police force is now up to 4,977 officers after Hochul congratulated 228 new troopers after they graduated from the academy today.

“Today’s graduates have dedicated themselves to a life of public service and are making a commitment to serve and protect all New Yorkers,” Hochul said in a statement.

Three different awards were also presented to a select few graduates. Nicholas Krafft was given the Academic Performance Award; Matthew Grant was given the Firearms Proficiency Award; and Dominick Battaglia was given the Investigator Joseph T. Aversa Physical Fitness Award.

“Today’s ceremony is one of our finest traditions and introduces a new generation of highly trained men and women to the New York State Police. These new Troopers will serve New Yorkers with honor, integrity, and bravery, and I welcome them to our ranks,” state police superintendent Steven James said in a statement. — Shawn Ness

POLL OBSERVER PUSH: Advocates are calling on lawmakers to pass a bill to let nonpartisan groups be certified to send neutral observers to poll sites on Election Day.

“In this highly polarized context, having neutral eyes on the ground to be able to verify what’s actually happening in our polling places, which 99 percent of the time is organized and exactly as we want to it be, helps to increase transparency and to improve the public’s faith in elections,” Common Cause New York executive director Susan Lerner said.

She noted that under current law, the only people who can be certified to be observers are picked by candidates and parties.

“This seems to be a pretty straightforward and commonsense solution to a problem that occasionally arises, where a voter is improperly turned away for whatever reason,” said state Sen. James Skoufis, who sponsors the bill with Assemblymember Amy Paulin. — Bill Mahoney

MIGRANT CRISIS: Assemblymember Ed Ra and other lawmakers in the GOP minority conference are calling for a legislative hearing with New York City officials and organizations that are under contract to provide migrant-related services.

The Times Union reported on Monday about ongoing concerns with one of the key vendors, DocGo.

“This year, the state budget allocated $2.4 billion to address the migrant crisis, a considerable expansion of an expenditure for New York’s taxpayers to shoulder. Without the guardrails needed for fiscal responsibility, these funds are at risk of the fraud and abuse we have become accustomed to with emergency government contracts that lack transparency and oversight guidance,” Ra, a Long Island Republican, said in a statement.

Republicans are also calling for the passage of one of Ra’s bills that would mandate the reporting and auditing on how money for migrant programs are being spent. It is co-sponsored by fellow Republicans. — Shawn Ness

— Two New York Democrats have reintroduced a federal bill that restricts the public’s access to body armor one day after the two-year anniversary of the Buffalo Tops shooting. (State of Politics)

— State legislators are working on passing a bill to incentivize emergency medical service providers to keep working. (Times Union)

— The Seneca Nation of Indians is still in tense negotiations with the state on its compact. (POLITICO Pro)

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